The gist is that you need to wire up the VTEC pressure switch and the VTEC solenoid to the ECU. Therefore you need to use a VTEC ECU, which has the correct hardware for those two things. A VTEC ECU will also have a program with two sets of fuel and ignition maps, and the ECU will switch from one set of maps to the other when it engages VTEC.

You can also use a VTEC controller, which has fuel correction tables that it uses when it engages VTEC, but you'll get usually get much better results and a better running engine with a stock VTEC ECU.

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