B16 Block
Low compression SRP pistons with Eagle Rods
GSR head, 3-angle valve job, mild bowl porting on exhaust side to increase low-lift flow.

T3/T4 Turbo (probably a 46 or 50 trim)

My reasoning: The lower stroke decreases compression and piston speeds. The GSR head has enhanced quiench pads. The valves will be de-shrouded in the chamber, and the chamber polished and worked on to reduce compression a bit more, and to enhance low-lift valve flow.
The block may be decked .005 as well as the heads, to give a .040 piston to head clearance, and ensure the surfaces are flat.

This should give me an ideal quench, improving the torque and mixture, and helping to seriously reduce the risk of knock. Further, the lower piston speeds will serve much the same function. Attention to ensuring there are no sharp edges to retain heat, and proper ceramic coatings inside the chamber and on the tops of the pistons should further reduce the possiblity of knock.

That should allow a reasonably aggressive tune, with a bit more boost, a more ideal Air/Fuel mix, and more power. The added boost should compensate for the lack of displacement.

Other possible modifications would include:
Lightweight, sodium-filled valves
Skunk2 Pro-Series Springs and Titanium Retainers
Low-Friction as opposed to stock rings
A turbo specific grind from Crane, Crower, or any other reputable manufacturer.

I'd like to get opinions from some of you here, as to how well the setup should perform, and what could be improved/what changes you would make.