Nope. There are no regular vehicle inspections in MD (and yet there aren't run down cars running amok everywhere and dangerous modification being made left and right...but here in VA they've decided they need to be a nanny state), only when the title changes hands there is a safety inspection, and if it's a vehicle that you bought at a dealer in-state you won't even know about this because the dealer takes care of it. So, if someone is like my dad and only buys vehicles from dealers, he could go his whole life without ever understanding why gas stations in MD have signs advertising inspection prices.

EDIT: I just realized OP said he has MD tags. If he already has the MD tags he should be ok, but I haven't experienced this precise situation before, so I don't know for sure.